Prince Paul-Louis Jean Marie Guillaume of Nassau (Prince Paul-Louis de Nassau) was born at Luxembourg-City, Luxembourg, on 4 March 1998.

Paul-Louis is the eldest child of Prince Guillaume of Luxembourg (born 1963) and his wife (since 1994) Sibilla Weiller (born 1968). Paul-Louis has two brothers, Léopold (born 2000) and Jean (born 2004), and one sister, Charlotte (born 2000).